Treatment of Hypertension in Patients 80 Years of Age or Older
Identifieur interne : 008956 ( Main/Exploration ); précédent : 008955; suivant : 008957Treatment of Hypertension in Patients 80 Years of Age or Older
Auteurs : Nigel S. Beckett [Royaume-Uni] ; Ruth Peters [Royaume-Uni] ; Astrid E. Fletcher [Royaume-Uni] ; Jan A. Staessen [Belgique] ; LISHENG LIU [République populaire de Chine] ; Dan Dumitrascu [Roumanie] ; Vassil Stoyanovsky [Bulgarie] ; Riitta L. Antikainen [Royaume-Uni, Finlande] ; Yuri Nikitin [Russie] ; Craig Anderson [Australie] ; Alli Belhani [Tunisie] ; Francoise Forette [France] ; Chakravarthi Rajkumar [Royaume-Uni] ; Lutgarde Thijs [Belgique] ; Winston Banya [Royaume-Uni] ; Christopher J. Bulpitt [Royaume-Uni]Source :
- The New England journal of medicine [ 0028-4793 ] ; 2008.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Personne âgée, Médecine.
English descriptors
Abstract
BACKGROUND Whether the treatment of patients with hypertension who are 80 years of age or older is beneficial is unclear. It has been suggested that antihypertensive therapy may reduce the risk of stroke, despite possibly increasing the risk of death. METHODS We randomly assigned 3845 patients from Europe, China, Australasia, and Tunisia who were 80 years of age or older and had a sustained systolic blood pressure of 160 mm Hg or more to receive either the diuretic indapamide (sustained release, 1.5 mg) or matching placebo. The angiotensin-converting-enzyme inhibitor perindopril (2 or 4 mg), or matching placebo, was added if necessary to achieve the target blood pressure of 150/80 mm Hg. The primary end point was fatal or nonfatal stroke. RESULTS The active-treatment group (1933 patients) and the placebo group (1912 patients) were well matched (mean age, 83.6 years; mean blood pressure while sitting, 173.0/90.8 mm Hg); 11.8% had a history of cardiovascular disease. Median follow-up was 1.8 years. At 2 years, the mean blood pressure while sitting was 15.0/6.1 mm Hg lower in the active-treatment group than in the placebo group. In an intention-to-treat analysis, active treatment was associated with a 30% reduction in the rate of fatal or nonfatal stroke (95% confidence interval [CI], -1 to 51; P=0.06), a 39% reduction in the rate of death from stroke (95% CI, 1 to 62; P=0.05), a 21% reduction in the rate of death from any cause (95% CI, 4 to 35; P=0.02), a 23% reduction in the rate of death from cardiovascular causes (95% CI, -1 to 40; P=0.06), and a 64% reduction in the rate of heart failure (95% CI, 42 to 78; P<0.001). Fewer serious adverse events were reported in the active-treatment group (358, vs. 448 in the placebo group; P= 0.001). CONCLUSIONS The results provide evidence that antihypertensive treatment with indapamide (sustained release), with or without perindopril, in persons 80 years of age or older is beneficial.
Affiliations:
- Australie, Belgique, Bulgarie, Finlande, France, Roumanie, Royaume-Uni, Russie, République populaire de Chine, Tunisie
- Angleterre, Gouvernorat de Tunis, Grand Londres, Nouvelle-Galles du Sud, Sofia-ville (oblast), Île-de-France
- Londres, Paris, Pékin, Sofia, Sydney, Tunis
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Beckett</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Imperial College London</s1><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>8 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Imperial College London</wicri:noRegion></affiliation></author><author><name sortKey="Peters, Ruth" sort="Peters, Ruth" uniqKey="Peters R" first="Ruth" last="Peters">Ruth Peters</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Imperial College London</s1><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>8 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Imperial College London</wicri:noRegion></affiliation></author><author><name sortKey="Fletcher, Astrid E" sort="Fletcher, Astrid E" uniqKey="Fletcher A" first="Astrid E." last="Fletcher">Astrid E. Fletcher</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>London School of Hygiene and Tropical Medicine</s1><s2>London</s2><s3>GBR</s3><sZ>3 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Staessen, Jan A" sort="Staessen, Jan A" uniqKey="Staessen J" first="Jan A." last="Staessen">Jan A. Staessen</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>University of Leuven</s1><s2>Leuven</s2><s3>BEL</s3><sZ>4 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>University of Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Lisheng Liu" sort="Lisheng Liu" uniqKey="Lisheng Liu" last="Lisheng Liu">LISHENG LIU</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Beijing Hypertension League Institute</s1><s2>Beijing</s2><s3>CHN</s3><sZ>5 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Dumitrascu, Dan" sort="Dumitrascu, Dan" uniqKey="Dumitrascu D" first="Dan" last="Dumitrascu">Dan Dumitrascu</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Spitaluljudetean Cluj, Clinica Medical 2</s1><s2>Cluj</s2><s3>ROU</s3><sZ>6 aut.</sZ></inist:fA14><country>Roumanie</country><wicri:noRegion>Cluj</wicri:noRegion></affiliation></author><author><name sortKey="Stoyanovsky, Vassil" sort="Stoyanovsky, Vassil" uniqKey="Stoyanovsky V" first="Vassil" last="Stoyanovsky">Vassil Stoyanovsky</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>National Transport Multi-Profile Hospital</s1><s2>Sofia</s2><s3>BGR</s3><sZ>7 aut.</sZ></inist:fA14><country>Bulgarie</country><placeName><settlement type="city">Sofia</settlement><region nuts="2">Sofia-ville (oblast)</region></placeName></affiliation></author><author><name sortKey="Antikainen, Riitta L" sort="Antikainen, Riitta L" uniqKey="Antikainen R" first="Riitta L." last="Antikainen">Riitta L. 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Bulpitt</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Imperial College London</s1><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>8 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Imperial College London</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">08-0239539</idno><date when="2008">2008</date><idno type="stanalyst">PASCAL 08-0239539 INIST</idno><idno type="RBID">Pascal:08-0239539</idno><idno type="wicri:Area/PascalFrancis/Corpus">003599</idno><idno type="wicri:Area/PascalFrancis/Curation">002A48</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">002E10</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">002E10</idno><idno type="wicri:doubleKey">0028-4793:2008:Beckett N:treatment:of:hypertension</idno><idno type="wicri:Area/Main/Merge">009224</idno><idno type="wicri:Area/Main/Curation">008956</idno><idno type="wicri:Area/Main/Exploration">008956</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Treatment of Hypertension in Patients 80 Years of Age or Older</title><author><name sortKey="Beckett, Nigel S" sort="Beckett, Nigel S" uniqKey="Beckett N" first="Nigel S." last="Beckett">Nigel S. Beckett</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Imperial College London</s1><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>8 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Imperial College London</wicri:noRegion></affiliation></author><author><name sortKey="Peters, Ruth" sort="Peters, Ruth" uniqKey="Peters R" first="Ruth" last="Peters">Ruth Peters</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Imperial College London</s1><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>8 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Imperial College London</wicri:noRegion></affiliation></author><author><name sortKey="Fletcher, Astrid E" sort="Fletcher, Astrid E" uniqKey="Fletcher A" first="Astrid E." last="Fletcher">Astrid E. Fletcher</name><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>London School of Hygiene and Tropical Medicine</s1><s2>London</s2><s3>GBR</s3><sZ>3 aut.</sZ></inist:fA14><country>Royaume-Uni</country><placeName><settlement type="city">Londres</settlement><region type="country">Angleterre</region><region type="région" nuts="1">Grand Londres</region></placeName></affiliation></author><author><name sortKey="Staessen, Jan A" sort="Staessen, Jan A" uniqKey="Staessen J" first="Jan A." last="Staessen">Jan A. Staessen</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>University of Leuven</s1><s2>Leuven</s2><s3>BEL</s3><sZ>4 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>University of Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Lisheng Liu" sort="Lisheng Liu" uniqKey="Lisheng Liu" last="Lisheng Liu">LISHENG LIU</name><affiliation wicri:level="3"><inist:fA14 i1="04"><s1>Beijing Hypertension League Institute</s1><s2>Beijing</s2><s3>CHN</s3><sZ>5 aut.</sZ></inist:fA14><country>République populaire de Chine</country><placeName><settlement type="city">Pékin</settlement></placeName></affiliation></author><author><name sortKey="Dumitrascu, Dan" sort="Dumitrascu, Dan" uniqKey="Dumitrascu D" first="Dan" last="Dumitrascu">Dan Dumitrascu</name><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Spitaluljudetean Cluj, Clinica Medical 2</s1><s2>Cluj</s2><s3>ROU</s3><sZ>6 aut.</sZ></inist:fA14><country>Roumanie</country><wicri:noRegion>Cluj</wicri:noRegion></affiliation></author><author><name sortKey="Stoyanovsky, Vassil" sort="Stoyanovsky, Vassil" uniqKey="Stoyanovsky V" first="Vassil" last="Stoyanovsky">Vassil Stoyanovsky</name><affiliation wicri:level="3"><inist:fA14 i1="06"><s1>National Transport Multi-Profile Hospital</s1><s2>Sofia</s2><s3>BGR</s3><sZ>7 aut.</sZ></inist:fA14><country>Bulgarie</country><placeName><settlement type="city">Sofia</settlement><region nuts="2">Sofia-ville (oblast)</region></placeName></affiliation></author><author><name sortKey="Antikainen, Riitta L" sort="Antikainen, Riitta L" uniqKey="Antikainen R" first="Riitta L." last="Antikainen">Riitta L. Antikainen</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Imperial College London</s1><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>8 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Imperial College London</wicri:noRegion></affiliation><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>University of Oulu</s1><s2>Oulu</s2><s3>FIN</s3><sZ>8 aut.</sZ></inist:fA14><country>Finlande</country><wicri:noRegion>University of Oulu</wicri:noRegion></affiliation></author><author><name sortKey="Nikitin, Yuri" sort="Nikitin, Yuri" uniqKey="Nikitin Y" first="Yuri" last="Nikitin">Yuri Nikitin</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>State Scientific Research Institute of Internal Medicine</s1><s2>Novosibirsk</s2><s3>RUS</s3><sZ>9 aut.</sZ></inist:fA14><country>Russie</country><wicri:noRegion>State Scientific Research Institute of Internal Medicine</wicri:noRegion></affiliation></author><author><name sortKey="Anderson, Craig" sort="Anderson, Craig" uniqKey="Anderson C" first="Craig" last="Anderson">Craig Anderson</name><affiliation wicri:level="3"><inist:fA14 i1="09"><s1>George Institute for International Health</s1><s2>Sydney</s2><s3>AUS</s3><sZ>10 aut.</sZ></inist:fA14><country>Australie</country><placeName><settlement type="city">Sydney</settlement><region type="état">Nouvelle-Galles du Sud</region></placeName></affiliation></author><author><name sortKey="Belhani, Alli" sort="Belhani, Alli" uniqKey="Belhani A" first="Alli" last="Belhani">Alli Belhani</name><affiliation wicri:level="3"><inist:fA14 i1="10"><s1>L'Etablissement Public de Santé Charles Nicolle, Service de Cardiologie</s1><s2>Tunis</s2><s3>TUN</s3><sZ>11 aut.</sZ></inist:fA14><country>Tunisie</country><placeName><settlement type="city">Tunis</settlement><region nuts="2">Gouvernorat de Tunis</region></placeName></affiliation></author><author><name sortKey="Forette, Francoise" sort="Forette, Francoise" uniqKey="Forette F" first="Francoise" last="Forette">Francoise Forette</name><affiliation wicri:level="3"><inist:fA14 i1="11"><s1>Hôpital Broca, University Paris V</s1><s2>Paris</s2><s3>FRA</s3><sZ>12 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Rajkumar, Chakravarthi" sort="Rajkumar, Chakravarthi" uniqKey="Rajkumar C" first="Chakravarthi" last="Rajkumar">Chakravarthi Rajkumar</name><affiliation wicri:level="1"><inist:fA14 i1="12"><s1>Brighton and Sussex Medical School</s1><s2>Brighton</s2><s3>GBR</s3><sZ>13 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Brighton and Sussex Medical School</wicri:noRegion></affiliation></author><author><name sortKey="Thijs, Lutgarde" sort="Thijs, Lutgarde" uniqKey="Thijs L" first="Lutgarde" last="Thijs">Lutgarde Thijs</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>University of Leuven</s1><s2>Leuven</s2><s3>BEL</s3><sZ>4 aut.</sZ><sZ>14 aut.</sZ></inist:fA14><country>Belgique</country><wicri:noRegion>University of Leuven</wicri:noRegion></affiliation></author><author><name sortKey="Banya, Winston" sort="Banya, Winston" uniqKey="Banya W" first="Winston" last="Banya">Winston Banya</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Imperial College London</s1><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>8 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Imperial College London</wicri:noRegion></affiliation></author><author><name sortKey="Bulpitt, Christopher J" sort="Bulpitt, Christopher J" uniqKey="Bulpitt C" first="Christopher J." last="Bulpitt">Christopher J. Bulpitt</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Imperial College London</s1><s3>GBR</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>8 aut.</sZ><sZ>15 aut.</sZ><sZ>16 aut.</sZ></inist:fA14><country>Royaume-Uni</country><wicri:noRegion>Imperial College London</wicri:noRegion></affiliation></author></analytic><series><title level="j" type="main">The New England journal of medicine</title><title level="j" type="abbreviated">N. Engl. j. med.</title><idno type="ISSN">0028-4793</idno><imprint><date when="2008">2008</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">The New England journal of medicine</title><title level="j" type="abbreviated">N. Engl. j. med.</title><idno type="ISSN">0028-4793</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age</term><term>Elderly</term><term>Hypertension</term><term>Medicine</term><term>Patient</term><term>Treatment</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Hypertension artérielle</term><term>Traitement</term><term>Malade</term><term>Personne âgée</term><term>Age</term><term>Médecine</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Personne âgée</term><term>Médecine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">BACKGROUND Whether the treatment of patients with hypertension who are 80 years of age or older is beneficial is unclear. It has been suggested that antihypertensive therapy may reduce the risk of stroke, despite possibly increasing the risk of death. METHODS We randomly assigned 3845 patients from Europe, China, Australasia, and Tunisia who were 80 years of age or older and had a sustained systolic blood pressure of 160 mm Hg or more to receive either the diuretic indapamide (sustained release, 1.5 mg) or matching placebo. The angiotensin-converting-enzyme inhibitor perindopril (2 or 4 mg), or matching placebo, was added if necessary to achieve the target blood pressure of 150/80 mm Hg. The primary end point was fatal or nonfatal stroke. RESULTS The active-treatment group (1933 patients) and the placebo group (1912 patients) were well matched (mean age, 83.6 years; mean blood pressure while sitting, 173.0/90.8 mm Hg); 11.8% had a history of cardiovascular disease. Median follow-up was 1.8 years. At 2 years, the mean blood pressure while sitting was 15.0/6.1 mm Hg lower in the active-treatment group than in the placebo group. In an intention-to-treat analysis, active treatment was associated with a 30% reduction in the rate of fatal or nonfatal stroke (95% confidence interval [CI], -1 to 51; P=0.06), a 39% reduction in the rate of death from stroke (95% CI, 1 to 62; P=0.05), a 21% reduction in the rate of death from any cause (95% CI, 4 to 35; P=0.02), a 23% reduction in the rate of death from cardiovascular causes (95% CI, -1 to 40; P=0.06), and a 64% reduction in the rate of heart failure (95% CI, 42 to 78; P<0.001). Fewer serious adverse events were reported in the active-treatment group (358, vs. 448 in the placebo group; P= 0.001). CONCLUSIONS The results provide evidence that antihypertensive treatment with indapamide (sustained release), with or without perindopril, in persons 80 years of age or older is beneficial.</div></front></TEI><affiliations><list><country><li>Australie</li><li>Belgique</li><li>Bulgarie</li><li>Finlande</li><li>France</li><li>Roumanie</li><li>Royaume-Uni</li><li>Russie</li><li>République populaire de Chine</li><li>Tunisie</li></country><region><li>Angleterre</li><li>Gouvernorat de Tunis</li><li>Grand Londres</li><li>Nouvelle-Galles du Sud</li><li>Sofia-ville (oblast)</li><li>Île-de-France</li></region><settlement><li>Londres</li><li>Paris</li><li>Pékin</li><li>Sofia</li><li>Sydney</li><li>Tunis</li></settlement></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Beckett, Nigel S" sort="Beckett, Nigel S" uniqKey="Beckett N" first="Nigel S." last="Beckett">Nigel S. Beckett</name></noRegion><name sortKey="Antikainen, Riitta L" sort="Antikainen, Riitta L" uniqKey="Antikainen R" first="Riitta L." last="Antikainen">Riitta L. Antikainen</name><name sortKey="Banya, Winston" sort="Banya, Winston" uniqKey="Banya W" first="Winston" last="Banya">Winston Banya</name><name sortKey="Bulpitt, Christopher J" sort="Bulpitt, Christopher J" uniqKey="Bulpitt C" first="Christopher J." last="Bulpitt">Christopher J. Bulpitt</name><name sortKey="Fletcher, Astrid E" sort="Fletcher, Astrid E" uniqKey="Fletcher A" first="Astrid E." last="Fletcher">Astrid E. Fletcher</name><name sortKey="Peters, Ruth" sort="Peters, Ruth" uniqKey="Peters R" first="Ruth" last="Peters">Ruth Peters</name><name sortKey="Rajkumar, Chakravarthi" sort="Rajkumar, Chakravarthi" uniqKey="Rajkumar C" first="Chakravarthi" last="Rajkumar">Chakravarthi Rajkumar</name></country><country name="Belgique"><noRegion><name sortKey="Staessen, Jan A" sort="Staessen, Jan A" uniqKey="Staessen J" first="Jan A." last="Staessen">Jan A. Staessen</name></noRegion><name sortKey="Thijs, Lutgarde" sort="Thijs, Lutgarde" uniqKey="Thijs L" first="Lutgarde" last="Thijs">Lutgarde Thijs</name></country><country name="République populaire de Chine"><noRegion><name sortKey="Lisheng Liu" sort="Lisheng Liu" uniqKey="Lisheng Liu" last="Lisheng Liu">LISHENG LIU</name></noRegion></country><country name="Roumanie"><noRegion><name sortKey="Dumitrascu, Dan" sort="Dumitrascu, Dan" uniqKey="Dumitrascu D" first="Dan" last="Dumitrascu">Dan Dumitrascu</name></noRegion></country><country name="Bulgarie"><region name="Sofia-ville (oblast)"><name sortKey="Stoyanovsky, Vassil" sort="Stoyanovsky, Vassil" uniqKey="Stoyanovsky V" first="Vassil" last="Stoyanovsky">Vassil Stoyanovsky</name></region></country><country name="Finlande"><noRegion><name sortKey="Antikainen, Riitta L" sort="Antikainen, Riitta L" uniqKey="Antikainen R" first="Riitta L." last="Antikainen">Riitta L. Antikainen</name></noRegion></country><country name="Russie"><noRegion><name sortKey="Nikitin, Yuri" sort="Nikitin, Yuri" uniqKey="Nikitin Y" first="Yuri" last="Nikitin">Yuri Nikitin</name></noRegion></country><country name="Australie"><region name="Nouvelle-Galles du Sud"><name sortKey="Anderson, Craig" sort="Anderson, Craig" uniqKey="Anderson C" first="Craig" last="Anderson">Craig Anderson</name></region></country><country name="Tunisie"><region name="Gouvernorat de Tunis"><name sortKey="Belhani, Alli" sort="Belhani, Alli" uniqKey="Belhani A" first="Alli" last="Belhani">Alli Belhani</name></region></country><country name="France"><region name="Île-de-France"><name sortKey="Forette, Francoise" sort="Forette, Francoise" uniqKey="Forette F" first="Francoise" last="Forette">Francoise Forette</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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